Samstag, 31. März 2012

The Best Way To Raise Online Traffic Employing Search Engine ...

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Amyloid beta in the brain of individuals with Alzheimer's disease

Amyloid beta in the brain of individuals with Alzheimer's disease [ Back to EurekAlert! ] Public release date: 30-Mar-2012
[ | E-mail | Share Share ]

Contact: Chris Stone
c.w.stone@mac.keele.ac.uk
44-178-273-3375
IOS Press

The deposition of amyloid beta in the brain of individuals with Alzheimer's disease is the focus of much research into both its cause and treatment.

While there may not be a consensus as to whether the deposition contributes to the disease or is a consequence of the disease, there is agreement that it is not favoured thermodynamically, meaning that something else is promoting the process.

Other proteins are often co-deposited in vivo with amyloid beta and one such protein is serum amyloid P component (or SAP). Recent evidence has suggested that SAP is elevated in Alzheimer's disease and a team of researchers from Keele University in Staffordshire, UK, led by Professor Chris Exley, has shown that physiologically-significant concentrations of SAP promote the deposition of amyloid beta under conditions approaching those found in vivo.

Professor Exley said: "We have shown that SAP is bound by fibrils of amyloid beta and that this interaction stabilises the fibrils over timescales which are physiologically significant. This is the first example of a physiologically significant biomolecule promoting and stabilising the formation of amyloid fibrils of amyloid beta 42 under near-physiological conditions."

The group also found that this property of SAP was enhanced in the presence of aluminium, a metal which has also been shown to be co-deposited with amyloid beta in Alzheimer's disease. There have been recent efforts to reduce the plasma concentration of SAP as a therapy for Alzheimer's disease and the research provides strong evidence that SAP is involved in the deposition of amyloid beta 42 in Alzheimer's disease and that by reducing the plasma concentration of SAP it might also reduce the deposition of amyloid beta. Their observations support serum amyloid P component as a therapeutic target in Alzheimer's disease.

###



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Amyloid beta in the brain of individuals with Alzheimer's disease [ Back to EurekAlert! ] Public release date: 30-Mar-2012
[ | E-mail | Share Share ]

Contact: Chris Stone
c.w.stone@mac.keele.ac.uk
44-178-273-3375
IOS Press

The deposition of amyloid beta in the brain of individuals with Alzheimer's disease is the focus of much research into both its cause and treatment.

While there may not be a consensus as to whether the deposition contributes to the disease or is a consequence of the disease, there is agreement that it is not favoured thermodynamically, meaning that something else is promoting the process.

Other proteins are often co-deposited in vivo with amyloid beta and one such protein is serum amyloid P component (or SAP). Recent evidence has suggested that SAP is elevated in Alzheimer's disease and a team of researchers from Keele University in Staffordshire, UK, led by Professor Chris Exley, has shown that physiologically-significant concentrations of SAP promote the deposition of amyloid beta under conditions approaching those found in vivo.

Professor Exley said: "We have shown that SAP is bound by fibrils of amyloid beta and that this interaction stabilises the fibrils over timescales which are physiologically significant. This is the first example of a physiologically significant biomolecule promoting and stabilising the formation of amyloid fibrils of amyloid beta 42 under near-physiological conditions."

The group also found that this property of SAP was enhanced in the presence of aluminium, a metal which has also been shown to be co-deposited with amyloid beta in Alzheimer's disease. There have been recent efforts to reduce the plasma concentration of SAP as a therapy for Alzheimer's disease and the research provides strong evidence that SAP is involved in the deposition of amyloid beta 42 in Alzheimer's disease and that by reducing the plasma concentration of SAP it might also reduce the deposition of amyloid beta. Their observations support serum amyloid P component as a therapeutic target in Alzheimer's disease.

###



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


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RIM posts loss as new CEO begins to clean house

TORONTO (Reuters) - Research In Motion posted a net loss and its first slump in BlackBerry shipments for its holiday quarter since 2006, as its new CEO announced the initial steps in a strategic overhaul and would not rule out an eventual sale of the company.

RIM's shares dropped as much as 9 percent on Thursday after the company said it would no longer issue financial forecasts and was reviewing "strategic opportunities" such as partnerships and joint-venture licensing, and other ways to leverage its assets. A handful of senior executives, including former co-CEO and current director Jim Balsillie, will depart.

Chief Executive Thorsten Heins, who took over from Balsillie and co-CEO Mike Lazaridis in January, said he was still focusing on a turnaround of the company, which has been hammered by competition from Apple and Google's Android in recent years.

Even so, if the review pointed in the direction of a possible sale, he said, "We would consider it, but it is not the main direction we are pursuing right now."

"I did my own reality check on where the entire company really is," he said during a conference call with analysts. "It is now very clear to me that substantial change is what RIM needs."

After Heins spoke, RIM's shares settled about 2.4 percent lower, in part because he left open the option of partnerships that analysts said could allow the company to exit some aspects of its business, such as making hardware, while focusing on software and services.

"If you look at this quarter alone ... things are certainly incrementally worse. But on the flip side, he's raised some possibilities of strategy change, which a lot of people think is called for," Avian Securities analyst Matthew Thornton said.

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For RIM graphic: http://link.reuters.com/keb47s

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Investors may also have been encouraged by signs that Heins was putting his stamp on the company. RIM said Balsillie, who long served as RIM's public face, was stepping down as a board director a few weeks after he gave up his role as co-CEO.

Dan Dodge, former head of QNX Software, will replace David Yach as RIM's top software architect. RIM bought QNX in 2010 and is counting on the operating system to power its PlayBook tablet and redesigned BlackBerry 10 smartphones that will be launched later this year.

In addition, Jim Rowan also left as chief operating officer and RIM is looking for his replacement. It is still searching for a chief marketing officer to lead its promotional efforts.

BLACKBERRY SHIPMENTS SLUMP

The Waterloo, Ontario-based company shipped 11.1 million BlackBerry smartphones in the fiscal fourth quarter ended March 3, down 21 percent from the third quarter, but slightly ahead of analysts' pessimistic expectations.

It was the first decline in the quarter covering Christmas since 2006 and only the second time RIM has reported the metric dropping for that crucial period.

RIM sold more than 500,000 PlayBooks in the fourth quarter, a number inflated by deep discounts offered to boost sales of the product.

The decline in BlackBerry shipments suggests that RIM, at best, is treading water until it releases its next-generation of BlackBerry smartphones. Most analysts consider that a do-or-die launch for the company as it falls further behind Apple Inc's iPhone and iPad and devices powered by Google's Android.

"PAYING THE PRICE"

The company is now paying the price for failing to heed calls to move quickly to license its operating system and consider other strategies to compete with industry titan Apple, said Peter Misek, managing director of Jefferies & Co.

"It's going to be absolute gong show for the next few quarters," he said. "They're going to scramble around now for the next three to six months, and every poor shareholder that had faith in them is going to be potentially impoverished. I'm so angry as a Canadian - every Canadian investor should be angry."

While analysts generally approved of the more candid tone by Heins compared with that of his predecessors, most questioned if the new CEO would have enough time to pull off his plans.

"RIM has to orchestrate this turnaround within a shrinking window of opportunity. The market will determine how long that window stays open," said CCS Insight analyst John Jackson.

"Ultimately, RIM is taking half measures, baby-stepping their way to a reorganization and they're not moving fast enough," said Ed Snyder, an analyst with Charter Equity Research. "They need a wholesale change in the culture and the management of the company."

GUIDANCE WITHHELD

RIM said its decision to no longer provide specific financial guidance reflected an inability to forecast accurately given the weakness of its U.S. business and competitive pressure in global markets as it increasingly relies on sales of more low-end devices.

RIM, which has historically provided a forecast for BlackBerry shipments, earnings per share and revenue, has faced scathing criticism in the past year for missing its targets. Last year it stopped reporting average selling prices and subscriber additions.

For its fourth quarter, RIM reported a net loss of $125 million, or 24 cents a share, after booking writedowns on its legacy BlackBerry 7 phones and goodwill.

RIM last recorded a loss under generally accepted accounting principles (GAAP) in the fourth quarter of fiscal 2005, when it booked tax expenses and paid to resolve a patent infringement case that had threatened to shut down its U.S. operations.

On an adjusted basis excluding the writedowns, profit in the latest quarter more than halved to $418 million, or 80 cents a share, from $934 million, or $1.78, a year earlier. Revenue slumped to $4.19 billion from $5.56 billion.

Analysts, on average, had expected RIM to earn 81 cents a share on revenue of $4.54 million, according to Thomson Reuters I/B/E/S.

Excluding several major writedowns, RIM had adjusted earnings of $4.20 per share in the full fiscal year, after forecasting a year ago it would earn more than $7.50 a share.

That target was cut several times before RIM abandoned it altogether after a spate of product delays, a global service outage and disappointing shipment numbers.

"They clearly have no fix on when this process will bottom, and until it really does, it's going to be very difficult for a lot of investors to come back in," said Eric Jackson, a hedge fund manager at Ironfire Capital in New York.

Shares of RIM were trading down 2.4 percent at $13.40 after the bell. Soon after the company released its results, the stock fell as much as 9 percent. The shares have fallen 80 percent since February 2011.

(Additional reporting by Susan Taylor, Allison Martell in Toronto, and Sinead Carew in New York; Writing by Cameron French; Editing by Frank McGurty)

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Freitag, 30. März 2012

Plukka Founder Joanne Ooi On Merging Manufacturing And Group Buying

Screen shot 2012-03-30 at 9.20.41 AMWe've seen a lot of group buying services cross the home page here at TechCrunch, and almost all of them have one thing in common: they sell you the stuff that has been marked down, and couldn't be sold at the time intended. But a new startup called Plukka, an e-commerce site focused on high-end designer jewelry, is going in an entirely different direction when it comes to group buying. I had the opportunity to sit down with founder Joanne Ooi, who stressed that the most important part of the Plukka equation is something she refers to as "just-in-time" manufacturing.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/8FAVIkZes5A/

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African leaders scrap Mali trip after runway invasion

[ [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['Afghan security forces and police killed three', 3]], 'http://yhoo.it/H9BcJE', '[Related: Bales\' wife on his alleged shooting: \'He would not do that\']', ' ', '630', ' ', ' ', ], [ [['looking for fireworks between the opposing camps', 16]], 'http://yhoo.it/GSvEsj', '[RELATED:\?It?s going to be a circus\?: Activists begin protests outside Supreme Court]', ' ', '630', ' ', ' ', ], [ [['entirely respectable way to put off the searing constitutional controversy', 8]], 'http://yhoo.it/GE6jSh', '[RELATED: Obama\?s health care law passed 2 years ago, but where are we now\?]', ' ', '630', ' ', ' ', ], [ [['Witnesses said the gunman pulled up on a black scooter', 7]], 'http://yhoo.it/GzwOIW', '[Related: New York police tighten security at Jewish sites]', ' ', '630', ' ', ' ', ], [ [['test Zimmerman for alcohol or drugs', 11]], 'http://yhoo.it/Gzn6VF', '[Related: White House says Trayvon Martin is local issue]', ' ', '630', ' ', ' ', ], [ [['Trayvon Martin decked the Neighborhood', 7]], 'http://yhoo.it/GUovUP', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/2/61/261d2c36bccf0971c2734a4d4398aa5a.jpeg', '512', ' ', 'AP/David Goldman', ], [ [['Can you create commerce in order to regulate it', 9]], 'http://yhoo.it/GSgtu8', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/7/78/778e2416573870cd705774e92403447d.jpeg', '630', ' ', 'AP/Charles Dharapak', ], [ [['associated with such a small earthquake', 4]], 'http://yhoo.it/GTco9z', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/0/b4/0b493c1a47b6e3f97f8f48a2b251d7d4.jpeg', '630', ' ', 'AP Photo/Carrie Antlfinger', ], [ [['Fox News host Geraldo Rivera sparked outrage', 3]], 'http://yhoo.it/GKMVTk', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/2/7c/27c7367bc512d233ae1790b320a5e92c.jpeg', '630', ' ', 'AP Photo/John Minchillo', ], [ [['The charges signed against Bales include', 1]], 'http://yhoo.it/wZT5zV', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/7/a0/7a07c51b2aa0f39b1a23355046d13870.jpeg', '512', ' ', 'AP Photo/DVIDS\, Spc\. Ryan Hallock\, File', ], [ [['George Zimmerman, if I had a son', 6]], 'http://news.yahoo.com/photos/thousands-protest-fla-teen-death-1332387124-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/os/152/2012/03/22/d761a49f3fcc99080a0f6a70670053cd-jpg_150905.jpg', '500', ' ', 'AP Photo/John Minchillo', ], [ [['Mohamed Merah', 10], ['prosecutor Francois Molins', 5]], 'http://news.yahoo.com/photos/four-dead-in-french-jewish-school-shooting-1332173151-slideshow', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120321/2012_03_21t151508z_425380421_gm1e83l1sqs01_rtrmadp_3_france_shootings_raid.jpg', '630', ' ', 'REUTERS/Jean-Paul Pelissier', ], [ [['Shortly after he wrapped up his victory remarks', 2]], 'http://news.yahoo.com/photos/4-straight-romney-wins-washington-gop-caucus-1330835515-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/3/e9/3e9b0082c3c3111dcc19e3527ae94cc7.jpeg', '500', ' ', 'AP Photo/Steven Senne', ], [ [['best understands the problems of average Americans', 2]], 'http://news.yahoo.com/photos/4-straight-romney-wins-washington-gop-caucus-1330835515-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/3/e9/3e9b0082c3c3111dcc19e3527ae94cc7.jpeg', '500', ' ', 'AP Photo/Steven Senne', ], [ [['Group for Historic Aircraft Recovery', 7]], 'http://yhoo.it/GB2RVy', 'Click image to see more photos', 'http://l.yimg.com/os/152/2012/03/20/photo-1332257995646-4-0-jpg_171722.jpg', '630', ' ', 'AFP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]

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Source: http://news.yahoo.com/africa-leaders-scrap-mali-visit-mid-flight-violence-131136355.html

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Girls soccer player dragged by hair, punched (video)

Suddenly the exploits of New Mexico?s Elizabeth Lambert seem like child?s play. An 18-year-old player from Lewisville High School in South Carolina took exception to being tripped during a soccer game, dragging her opponent to the ground by the hair and pummeling her. The attack was only stopped when spectators and a referee ran up and pulled the two apart.

Annette McCullough, 18, dragged the victim to the ground by her hair before punching her 11 times in the head and upper body as the girl curls up to protect herself. The attack happened during a soccer match between Chester High School and Lewisville High School on Monday.

?

More here.

Chester County Sheriff Richard Smith told WBTV that deputies were called to Lewisville High School to the report of an assault. McCullough is being charged with simple assault, according to the incident report from the Sheriff?s Office.

Referees will review the video with the South Carolina High School League to see if any punishments will be handed down.

***
Caught on camera: Teen girl attacked during soccer game [WBTV]

Source: http://offthebench.nbcsports.com/2012/03/29/girls-high-school-soccer-player-drags-opponent-by-hair-punches-her-11-times-video/related/

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Nine General Solutions for Hair Loss Problems


A healthy hair often mirrors a good blood circulation to the hair follicles because along the blood stream is the? the food and oxygen for the hair.

A myth holds it that the reason a man loses his hair only on the top of his head is that the blood flow to the top of the scalp is diminished than to the sides and the back of the head. This produced another myth about standing on one?s head to promote circulation to the area.

Another event that can restrict good circulation to the scalp is when the body is under severe stress. The small blood vessels in the follicles constrict, causing malnutrition to the follicles.

Solutions for Hair Loss

Indeed a proper circulation is important to induce proper hair growth.

Here are some general tips to promote proper circulation, thus avoid hair loss and importantly, achieve a healthy head of hair:

1. Iron is essential in the transportation of oxygen to all parts of the body including the follicles. Therefore, it is essential. Egg yolks, green leafy vegetables, wholegrain breads, cereals, and meat are good sources of iron.

2. Avoid caffeine since it can increase stress and weakens the adrenal glands. Also avoid sugar and refined carbohydrates because they can deplete the nutrients needed for hair growth.

3. The hair is basically protein so high-quality protein will be very good for the hair. Meat, fish, beans and pulses are excellent sources of such proteins.

4. Zinc is one of those very important minerals that the hair needs to grow.

In fact, it has been included in the formulations of several solutions for hair loss. Thirty milligrams of zinc a day should be enough to boost your hair condition.

5. For women who are using contraceptive pills, taking 50mg of vitamin B6 daily will be beneficial to offset the effects of the contraceptive pills to hair growth.

6. There are certain formulas that can keep the hair from breaking such as vitamins A, C, and D; silica; and cellulose.

7. Betaine hydrochloride improves the absorption of nutrients from good foods. Hence, taking this would optimize absorption of nutrients by the hair follicles at the same time. Those who have an active stomach ulcer, however, should refrain from taking this.

8. Nothing beats a good aerobic exercise in improving the blood circulation. Exercise will not only improve your heart?s condition but will specifically increase oxygen flow and reduce stress levels. Either way, exercise will definitely promote a better hair and scalp condition.

9. Look for hair loss clinics near you and ask for references of good hair loss specialists so you would know the varied solutions for hair loss.
?

Source: http://health.ezinemark.com/nine-general-solutions-for-hair-loss-problems-7d35255611b3.html

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Sons of Sugar Hill label founders face tax charges

(AP) ? Three sons of the founders of the Sugar Hill Records hip-hop recording label pleaded guilty Thursday to tax evasion charges.

Joseph Robinson Jr., 50, of Tenafly, and 46-year-old Leland Robinson and 41-year-old Rhondo Robinson, both of Englewood, entered their pleas in federal court in Newark.

The U.S. Attorney for the District of New Jersey said the Robinsons' failure to file resulted in nearly $1.3 million in tax losses to the government.

The men's primary source of income was royalties from the label their parents founded in 1979, prosecutors said. The men also made money as copyright administrators for different recording artists.

The Sugar Hill label was best known for releasing "Rapper's Delight," rap's first mainstream success. The company continued to play a part in the early years of hip-hop with a roster that included Grand Master Flash and the Furious Five. The label amassed an extensive music catalogue from 1979 until 1986.

The men's mother, Sylvia Robinson, who had a hit as a singer-songwriter with the sexually charged "Pillow Talk," and who some called "the mother of hip-hop" died in 2011.

Each of her sons pleaded to different counts Thursday, charging them with failing to file tax returns between the tax years 2005 through 2008.

Joseph Robinson pleaded guilty for failing to file taxes in 2005 and 2006, Leland Robinson for failure to file in 2006 and 2007, and Rhondo Robinson for his failure to file in 2005 and 2007.

Each defendant faces up to two years in prison and a $200,000 fine at their July 10 sentencing. They must also pay their back taxes and penalties, as well as the costs of prosecution

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2012-03-29-Rap%20Producers-Taxes/id-b1ca723853f647f099b9808cb469a05e

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Donnerstag, 29. März 2012

Structured Settlement Brokers: What They Do And Why You Need ...

Article by Simon Volkov

Structured settlement brokers assist in the development and negotiation of structured settlements. This type of financial arrangement is used to compensate individuals who have been seriously injured and provide consistent income over a specific period of time. Structured settlements are also used to compensate individuals who have won lottery jackpots or awarded a large sum of money through a lawsuit.

The role of structured settlement brokers is to advise attorneys on the different types of annuity plans available to their clients or to assist in the sale of structured settlements. Brokers provide detailed descriptions of settlement offers, answer questions relating to the offers, and help negotiate the best deal for the client.

Each structured settlement is unique; however, the main focus is to address both the current and future financial needs of the injured party. The monetary amount of the settlement is based on many factors including current and projected economic conditions and life expectancy of the Claimant.

Most structured settlements include upfront cash for attorney fees and medical expenses, along with annuity payment for future medical care, mortgage payments or rent, retirement income, or educational funds for dependents.

When developing a proposal the structured settlement broker must first assess detailed information about the individual who will receive the funds. Brokers must review the Claimant?s medical, credit and employment history and carefully analyze life care plans to ensure the individual is fully compensated for future medical and living expenses.

One of the first steps the structured settlement broker will take is to determine if the Claimant qualifies for a sub-standard age rating. Many factors are involved to determine the life expectancy of the injured party. These include smoking, alcohol consumption, heart disease, cancer, obesity, diabetes and other health issues.

Annuity payments are backed by life insurance companies. Insurance companies base their premiums on the level of risk. There are three ratings which include Preferred, Standard and Sub-standard. People with a sub-standard rating are oftentimes declined coverage. However, in the case of annuity payments a sub-standard rating may actually provide a better rate-of-return.

Structured settlement brokers have access to numerous life insurance companies and are able to shop around for the best annuity for the Claimant. Additionally, brokers can interact with Medicaid and Supplemental Security Income (SSI) if required, mediate negotiations and offer tax-planning and financial advice to the Claimant.

Annuity payments are not subject to income tax; however, investment proceeds are subject to taxation. Additionally, if annuity payments are payable to an estate they are subject to estate tax. Payments can be structured in any manner agreed upon by the parties involved. Annuity payments might be paid out monthly, semi-annually or annually; in equal installments or installments of varying amounts.

Once structured settlements are finalized they are no longer open for negotiation or change by either party. However, structured settlement payments can be sold for a lump sum cash payment. A structured settlement broker can assist with selling a portion or the whole settlement if the need arises.

When selling a structured settlement, it?s important to work with a broker who does not have an exclusive arrangement with the buyer. Trustworthy brokers have access to numerous buyers and will work on the seller?s behalf to obtain the best deal possible.

In order to obtain the best structured settlement arrangement, it?s important to work with a broker who is registered with the Department of Justice and insured against errors and omissions. Conduct research online to ensure the broker has a clean track record and can be trusted with sensitive information.

Source: http://structuredsettlementexpert.com/structured-settlement/structured-settlement-brokers-what-they-do-and-why-you-need-one/

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Mittwoch, 28. März 2012

Genetic abnormality offers diagnostic hope for children's cancer

Wednesday, March 28, 2012

A chromosomal abnormality in children with a deadly form of brain cancer is linked with a poorer chance of survival, clinician scientists at The University of Nottingham have discovered.

The study led by experts at Nottingham's Children's Brain Tumour Research Centre as part of a European collaboration could potentially lead to a new diagnostic test to allow doctors to identify youngsters who are at the highest risk associated with an ependymoma tumour and may need aggressive life-saving treatments.

The research could also help them to decide which children with the tumour have a better prognosis and would benefit from less intensive therapies, reducing their exposure to a range of side effects which can cause permanent disabilities, having a debilitating impact on them for the rest of their lives.

The study, published in the April 1 edition of the journal Clinical Cancer Research, focused on looking at abnormal copies of chromosomes in the cells of ependymoma tumours and aimed to establish whether it was associated with a worse outlook for children suffering from the disease.

The research, led by Professor Richard Grundy and Dr John-Paul Kilday, found that increased copies of a specific region of a chromosome called 1q25 were associated with around 20 per cent of the 147 tumours they tested from European children with ependymoma and that it was associated with a worse outcome in younger children treated with surgery and chemotherapy.

In addition, when combining the results for 1q25 copy gain with how much tumour was removed at the time of surgery, the scientists could accurately place the children into three risk groups ? high, intermediate and standard.

Dr Kilday said: "This study is the first to assess copy number gain like this in groups of children with ependymoma who have been treated in a similar way and is an important step forward in being able to predict the future for children with these brain tumours"

"We are now hoping that these findings are reproduced in other studies currently underway in other countries, including the USA" added Professor Grundy, "If their results match ours, then the presence of 1q25 copy gain in childhood ependymoma could be introduced into future international treatment planning as a new marker of poor outcome which will in turn define treatment. We would intend that this should be something each patient's tumour is tested for at the time of diagnosis."

Ependymomas are brain tumours that can occur at any age but are more common in children. Despite improvements in therapy over recent years, the prognosis for children with this cancer remains poor ? 40 per cent of affected children still die.

One of the reasons that survival for childhood ependymomas has not improved is that, until now, doctors have not been able to accurately predict which tumours will behave more or less aggressively than others. Factors that have helped the ability to predict outcomes in other cancers, such as patient sex, age, how much of the tumour is removed and how aggressive the tumour appears under the microscope, have not been found to be consistently reliable in previous studies.

In normal humans, the cells which make up our body tissue contain chromosomes made up of DNA and proteins ? the building blocks of life. Normally, our cells have two copies of 23 chromosomes (numbered 1 to 22) plus two sex chromosomes, making a total of 46 chromosomes. Each chromosome has two arms ? a short arm called the p arm and a long arm called the q arm.

In tumour cells the number of chromosomes can vary significantly from the normal cell numbers and in ependymoma a frequent finding from biological studies is increased copies of chromosome number 1, specifically increased numbers of the long arm of chromosome 1. This abnormality is termed 1q copy number gain.

For the Nottingham-led study, the scientists assessed the results from 147 brain ependymomas in young UK and French children who received tumour surgery followed by chemotherapy and older European children who received tumour surgery followed by radiotherapy.

Copy number gain of 1q in the ependymoma cells from each of the 147 patients was assessed using a technique called fluorescence in situ hybridisation (FISH) in which pieces of DNA called probes are made in the lab containing a fluorescent dye. This enables the tumour cells to be seen down a fluorescent microscope. In the Nottingham project, the scientists used a green probe that bound to a region within chromosome 1q of the tumour cells, called 1q25.

The team then linked which of the ependymomas had increased copies of the 1q25 probe in their cells to corresponding patient data to work out whether increased copy number gain was associated with a worse survival rate.

###

University of Nottingham: http://www.nottingham.ac.uk

Thanks to University of Nottingham for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 39 time(s).

Source: http://www.labspaces.net/118793/Genetic_abnormality_offers_diagnostic_hope_for_children_s_cancer

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Jason Segel and Michelle Williams: New Couple Alert!


The world of drama has met the world of comedy in one of Hollywood's newest, cutest couples.

Multiple sources confirm that Jason Segel is now dating Michelle Willliams, as the How I Met Your Mother star and three-time Oscar nominee are "smitten and very serious," according to Us Weekly.

Jason Segel PhotographMichelle Williams Academy Awards Dress

The tabloid has posted photos of Segel and Williams on March 24, walking through Brooklyn and, the following day, playing with Williams' six-year old daughter, Matilda.

The unexpected tandem reportedly met through the actress' close friend, Cougar Town star Busy Phillips. They were friends for awhile prior to ratcheting up the relationship to a romantic level.

"She hasn't been this happy in a long time," says an insider, who adds that the bi-coastal couple is "trying to make [the distance] work."

[Photos: WENN.com]

Source: http://www.thehollywoodgossip.com/2012/03/jason-segel-and-michelle-williams-new-couple-alert/

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OECD pushes for $1.3 trillion eurozone crisis fund

(AP) ? The 17 countries that use the euro should boost their crisis firewalls to at least ?1 trillion ($1.3 trillion) to help the struggling currency union return to growth, the head of the Organization for Economic Cooperation and Development said Tuesday.

Angel Gurria, the head of the Paris-based international development body, said current commitments to the rescue funds, which are limited to ?500 billion ($664 billion), are not enough to restore market confidence in the eurozone.

"A credible firewall will provide governments with the breathing space they need to focus on revitalizing Europe's economic growth and competitiveness," Gurria said in a statement linked to the release of the OECD's annual report on the eurozone economy. "Decisive action to restore confidence and support demand is needed now."

According to the report, which also spells out a raft of economic reforms for individual countries, vulnerable states may need more than ?1 trillion in aid over the coming two years.

Gurria said eurozone finance ministers should take a decision to boost their bailout funds at their meeting in Copenhagen later this week.

Germany, the bloc's largest economy, signaled on Monday that it would only support a temporary increase to around ?700 billion ($929 billion).

But that falls below the recommendation of the International Monetary Fund and the European Commission, the European Union's executive. It may also not be enough to convince other large non-euro economies, such as China and the U.S., to help in the beefing up of Europe's defenses by sending more money to the IMF.

International institutions argue that a big and credible bailout fund would restore confidence in vulnerable countries like Italy and Spain and prevent them from actually having to seek help.

Gurria said it could also allow weak economies to focus on kickstarting growth by reforming their economies.

"Europe is stalling," he said. "It needs to get out of first gear and make growth number one priority."

However, countries like Germany fear that easy access to financial support could stop countries from implementing reforms.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2012-03-27-EU-Europe-Financial-Crisis/id-3fcfe6263e4e42969a0595af98b91537

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Sonntag, 25. März 2012

Chamberlain to be released from hospital

FILE - In this June 13, 2011 photo, New York Yankees pitcher Joba Chamberlain looks on from the dugout during a baseball game against the Cleveland Indians at Yankee Stadium in New York. New York Yankees General manager Brian Cashman said Friday, March 23, 2012, that Chamberlain had surgery Thursday night and will be hospitalized for at least a few days. Cashman says the accident happened Thursday afternoon while Chamberlain and his son were at a Tampa-area spot that has trampoline equipment. The team is not saying whether Chamberlain was using any of the equipment. (AP Photo/Bill Kostroun)

FILE - In this June 13, 2011 photo, New York Yankees pitcher Joba Chamberlain looks on from the dugout during a baseball game against the Cleveland Indians at Yankee Stadium in New York. New York Yankees General manager Brian Cashman said Friday, March 23, 2012, that Chamberlain had surgery Thursday night and will be hospitalized for at least a few days. Cashman says the accident happened Thursday afternoon while Chamberlain and his son were at a Tampa-area spot that has trampoline equipment. The team is not saying whether Chamberlain was using any of the equipment. (AP Photo/Bill Kostroun)

In this April 29, 2011 photo, New York Yankees relief pitcher Joba Chamberlain (62) pitches in the eighth inning against the Toronto Blue Jays during a baseball game in New York. New York Yankees General manager Brian Cashman said Friday, March 23, 2012, that Chamberlain had surgery Thursday night and will be hospitalized for at least a few days. Cashman says the accident happened Thursday afternoon while Chamberlain and his son were at a Tampa-area spot that has trampoline equipment. The team is not saying whether Chamberlain was using any of the equipment. (AP Photo/Kathy Kmonicek)

(AP) ? Yankees reliever Joba Chamberlain is to be released from the hospital Sunday, three days after dislocating his right ankle bouncing on a trampoline.

New York general manager Brian Cashman announced the news before the Yankees' game against a Detroit Tigers split squad.

Chamberlain was hurt while playing with his son Thursday at a recreation spot. He needed surgery for the injury in which bone broke through the skin.

Cashman says Chamberlain will be in a nonweight-bearing cast for six weeks. There is no timetable for when the 26-year-old right-hander can resume pitching.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-03-25-BBA-Yankees-Chamberlain/id-bce441cde4ae47c3b6a788c24f7e270f

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Self-reflective mind -- in animals! Psychologists report on continuing advances

Friday, March 23, 2012

According to one of the leading scholars in the field, there is an emerging consensus among scientists that animals share functional parallels with humans' conscious metacognition -- that is, our ability to reflect on our own mental processes and guide and optimize them.

In two new contributions to this influential field of comparative psychology, David Smith, PhD, of the University at Buffalo and his fellow researchers report on continuing advances in this domain.

Smith is a professor in the Department of Psychology at UB, and a member of the university's graduate program in evolution, ecology and behavior and its Center for Cognitive Science. His co-authors on the articles are Justin J. Couchman, PhD, visiting assistant professor of psychology, State University of New York at Fredonia, and Michael J. Beran, PhD, senior research scientist, Language Research Center, Georgia State University.

In "The Highs and Lows of Theoretical Interpretation in Animal-Metacognition Research," in press at the journal Philosophical Transactions of the Royal Society, Smith, Couchman and Beran examine the theoretical and philosophical problems associated with the attribution of self-reflective, conscious mind to nonverbal animals.

Philosophical Transactions is a highly visible journal in the biological sciences and one of the oldest scientific journals published in English.

"The possibility of animal metacognition has become one of the research focal points in comparative psychology today," Smith says, "but, of course, this possibility poses difficult issues of scientific interpretation and inference." In this article, they evaluate the standards that science brings to making difficult interpretations about animal minds, describing how standards have been applied historically and as they perhaps should be applied. The article concludes that macaques do show uncertainty-monitoring capacities that are similar to those in humans.

The other contribution, "Animal Metacognition," will be published in March by Oxford University Press in the volume "Comparative Cognition: Experimental Explorations of Animal Intelligence." Smith says this volume will be one of the preeminent sources for scholarship in animal cognition for the next decade.

In this article, Smith and his colleagues provide a comprehensive review of the current state of the animal-metacognition literature. They describe how Smith inaugurated animal metacognition as a new field of study in 1995 with research on a bottlenosed dolphin. The dolphin assessed correctly when the experimenter's trials were too difficult for him, and adaptively declined to complete those trials.

The dolphin also showed his own distinctive set of hesitation, wavering and worrying behaviors when the trials were too difficult. In sharp contrast, when the trials were easy, he swam to the responses so fast that he would make a bow-wave around himself that would swamp Smith's delicate electronics. Smith says: "We finally had to buy condoms to protect the equipment."

Subsequently, Smith and many collaborators also explored the metacognitive capacities of joystick-trained macaques. These Old-World monkeys, native to Africa and Asia, can make specific responses to declare uncertainty about their memory. They can respond, "Uncertain," to gain hints from the experimenters of what to do on the first trial of new tasks. They can even respond, "Uncertain," when their memory has been erased by trans-cranial magnetic stimulation. Accordingly, this second article by Smith and colleagues also supports the consensus that animals share with humans a form of the self-reflective, metacognitive capacity.

"In all respects," says Smith, "their capacity for uncertainty monitoring, and for responding to uncertainty adaptively, show close correspondence to the same processes in humans.

"At present," he says, "members of South-American monkey species or New World monkeys have not shown the same robust capacities for uncertainty monitoring, a possible species difference that has intriguing implications regarding the emergence of reflective mind in monkeys, apes and humans."

###

University at Buffalo: http://www.buffalo.edu

Thanks to University at Buffalo for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 16 time(s).

Source: http://www.labspaces.net/118654/Self_reflective_mind____in_animals___Psychologists_report_on_continuing_advances

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Samstag, 24. März 2012

SES and Samsung unveil Africa's first TV with integrated free-to-air satellite receiver

SES (Euronext Paris and Luxembourg Stock Exchange: SESG) announced at the Samsung Africa Forum in Cape Town, South Africa, that it is collaborating with Samsung to drive digital broadcasting via satellite in sub-Saharan Africa. Samsung will introduce an LED television with an integrated free-to-air satellite receiver, the Samsung LED TV Free Satellite, that will be distributed in Nigeria, Ghana, Cote D?Ivoire, Senegal, Democratic Republic of Congo and Cameroon in August 2012. Distribution to additional countries will follow.

The integrated satellite receiver will allow consumers to receive free-to-air television channels without the need for an additional set top box as the LED TV will be directly connected with the satellite dish. In preparation for the launch, SES and Samsung will jointly arrange training sessions with distribution partners and installers to ensure the proper connection of the TV device to the satellite dish. Both partners will also run a joint marketing campaign in June 2012.

As a leader in the free-to-air digital TV market, SES delivers more than 60 free-to-air channels in more than 40 African countries. The launch of the new Samsung LED TV Free Satellite coincides with more channels becoming available in Africa.

"This collaboration is the first of its kind and will drive digitalization in Africa," said Christoph Limmer, SES's Senior Director of Marketing Development and Marketing in Africa. "Today, one out of three households in Africa has a TV set but less than 10 million homes receive content in digital format. Our cooperation will not only help to improve access to digital content for African consumers but it will also encourage African broadcasters to launch more content. In servicing more than 40 African countries, we are well aware of the huge demand for more and higher quality TV services. The opportunity lies in providing an increasingly sophisticated African viewership with a significantly increased number of TV channels - a first for many African countries."

"The Samsung LED TV Free Satellite is our contribution to the continent's efforts to 'go digital', providing African consumers with greater choice and broadcasters with the opportunity to grow the region's media industry," said Dae Hee Kim, Regional Product Manager at Samsung Africa.

About SES:

SES is a world-leading satellite operator with a fleet of 50 geostationary satellites. The company provides satellite communications services to broadcasters, content and internet service providers, mobile and fixed network operators and business and governmental organisations worldwide.

SES stands for long-lasting business relationships, high-quality service and excellence in the broadcasting industry. The culturally diverse regional teams of SES are located around the globe and work closely with customers to meet their specific satellite bandwidth and service requirements. SES (Euronext Paris and Luxembourg Stock Exchange: SESG) holds participations in Ciel in Canada and QuetzSat in Mexico, as well as a strategic participation in satellite infrastructure start-up O3b Networks. Further information under: www.ses.com.

For further information please contact:

Markus Payer
Market Communication & PR
Ch?teau de Betzdorf?
L-6815 Betzdorf?
Luxembourg
+352 710 725 500
www.ses.com

Source: http://feedproxy.google.com/~r/ReleaseWireConsumerTechnology/~3/NkMaI8Wn3a4/rel_display.php

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Video: Oil Shock & Gas Tax

CNBC's Sharon Epperson reports oil spiked past $108 on Friday, and research from Citi shows North America could become the fastest growing oil and gas region in the world within the next decade. Also, debating whether taxing big oil will bring down pri...

Source: http://video.msnbc.msn.com/cnbc/46840709/

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Freitag, 23. März 2012

Adventures fishing comforts at this area

Hawaii Tours is the best place where you will feel the real excitement of dinning and calm sea comforts. There are many activities held at this place they are sun sightseeing, grand circle island tour, Pearl Harbor, paradise comforts are the best way to move with. In the seeing you can join the dinning and winning of the best patterned sectors. Family comforts with real best hotels with high class facilities. Volcano's trip to make the tour a perfect match. Helicopter with best travelling comforts. You can fly in the air ands visit all the places in a very low rate.

Sunset dinner cruise are the best adventure in the travelling comfort. Sub marine moving in the sea is the tremendous effect of shipping into the season times. The guides will provide you best hotels and attractions at this place. The guide will help you to know the places. They will stop at major places to make the dine really perfect and show you the best seasonal effect at all the places.

We are able to view the best fantastic places of ever comforts. You can book the facilities through the online itself. The incredible magical place will make you really attractive with sunset shinning.

Deep sea sportfishing Hawaii rocks with the real magical appearance of best fishing comforts and style. The beautiful sand that blush with green vegetarian comforts. The place is full of natural beauty surrounded by waters at all the sides. Two mountains stand majestically at both the sides. The giant whales can be seen at this place. During season times the fishes are seen aboundately. Make use of the season time comforts with best move over. Dolphins dance with real excitement and fun. Watching the volcanoes is the real excitement at this place.

When you go deeper into the sea you will get many fishes of great extent.
People who come to this place will never forget to enter again. Many experienced fisher man are there at this place to make a perfect blend of catching the fish. Blue marlin catching is the best biggest catch dream of all the visitors you welcome to this place. Low rate and high rate charter are available in the online. It is always best to pick up good charter and good captain when you accommodate in fishing. The breath taking part is that it has unique best islands and distinct experience.

Source: http://leisure.ezinemark.com/adventures-fishing-comforts-at-this-area-18df6ffe35c.html

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Donnerstag, 22. März 2012

Pot charges for man who violated Obama LA airspace

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Source: http://news.yahoo.com/pot-charges-man-violated-obama-la-airspace-022726028.html

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The world's most beautiful spring flowers

Steve Ann Toon / Corbis

The King protea (Protea cynaroides) is the national flower of South Africa.

By Laura Kiniry , Frommers.com

If you don't know when and where to see the best blossoms, chances are you won't -- the timing of the prettiest blooms varies by region and can last just a few weeks.

Whether you want to see Arizona's wildflowers or Scotland's heather, you won't want to miss these six great destinations.

Slideshow: See these and other colorful spring blooms

Wildflowers in Southern Arizona

When to go:?It really depends on rainfall, but typically March and April. This is when the hills and roadsides across southern Arizona pop with?red, gold and blue. The region is best known for bright yellow brittlebush and Mexican gold poppies. You may also see wildflowers ranging from African daises to the bright-orange desert globemallow.

Where to see the best flowers:?Picacho Peak State Park?(the name means "Big Peak" in Spanish), about 45 miles northwest of Tucson and 60 miles south of Phoenix along Interstate 10. Several hiking trails -- including the easy Children's Cave Trail -- offer closer views.

Greenery of Italy's Tuscany region

When to go:?May, when?Tuscany's countryside is covered with the lush greens of grape vines, olive groves and cypress trees. Many towns throughout the region host parties and festivals to celebrate the season. Along with the greenery, keep an eye out for crimson-colored poppies as well as plenty of lilacs, rosemary and wisteria.?

Where to see the best flowers:?Head to Tuscany's many vineyards and olive groves. Held in Montespertoli in Tuscany's?Chianti?wine region, the Chianti Wine Festival takes place May 26 to June 3, 2012.

Wildflowers in Sweden

When to go:?May and June, after the snow has melted and when the Swedish countryside is bathing in bluets, poppies and marguerite daises. The country also boasts 45 varietals of orchids. At this time of year, the sun above the country's northern half never really sets, offering more time to appreciate spring's beauty.

Where to see the best flowers:?Lapland's?Sarek National Park in northern Sweden is a wildflower hotspot accessible to more seasoned hikers. The island of Gotland (accessible by ferry from greater Stockholm) off Sweden's east coast is home to 35 of the country's 45 orchid varieties.

Heather in Scotland

When to go:?July to September. While heather is not exclusive to Scotland, it's hard to think of one without the other. Come late summer or early fall, the Scottish Highlands are awash in soft lavender shades. You'll find heather growing throughout forests, across moors, and within bogs.?

Where to see the best flowers:?Heather is abundant throughout all of Scotland by August. Hotspots include the heather garden of?Threave Castle?in Dumfries and Galloway;?Cairngorms National Park?(heather moorland covers more than 41?percent of the park's landscape) in northeast Scotland; and the highroads around South Loch Ness.

Wildflowers of South Africa

When to go:?July through October (the country's spring season). South Africa's semi-desert landscape springs to life with hues of purple, yellow and orange, most notably during August and September.?

Where to see the best flowers:?About a five-hour drive north of Cape Town,?Namaqualand?is a wildflower paradise. Stop by the region's?Goegap Nature Reserve, a great place to picnic among more than 600 indigenous plant species. Overnight accommodations are nearby. One hour west of?Cape Town?along the coast, you'll find the village of Darling, host to September's annual Darling Wildflower Show for nearly 100 years.

Orchids & rhododendrons in Bhutan

When to go:?Late March to May are the best months to admire the country's flowering plants, orchids and rhododendrons. Though generally elusive, the Himalayan blue poppy -- Bhutan's national flower -- may be seen on treks around the country's Gangkhar Puensum region, notably in June and July. Expect to see buttercups, larkspurs, lilies and geraniums at higher elevations. The more temperate regions are covered in orchids, violets, and white, pink and red rhododendrons.

Where to see the best flowers:?Mountain passes such as Dochula Pass and Pelela Pass are prime areas to see wildflowers. The Chele La Nature Trek, which offers a panoramic view of the higher Himalayas, is lined with blue poppy, orchids, and rhododendron varietals.

More from Frommers.com

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Source: http://itineraries.msnbc.msn.com/_news/2012/03/15/10703226-the-worlds-most-beautiful-spring-flowers

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Mittwoch, 21. März 2012

Free Article Directory ? Dr. Terry McCormick DAOM Fraudulently ...

NewYork York Self-control motion Here

http://www.op.nysed.gov/opd/feb12.htm#mcco

Terence MCormick,

Occupation: Acupuncturist; Lic. No. 001396; Cal. No. 26048

Regents Action Day: February 14, 2012

Action: Software to surrender license granted.

Summary: Licensee admitted to fees of getting acquired his license fraudulently, owning been convicted of Giving a Phony Instrument for Submitting from the 1st Degree, and owning filed a fake report.

Oregon Clinical Board vs. Dr. Terry McCormick DAOM

Genuine Document the following:

https://techmedweb.omb.state.or.us/Clients/ORMB/OrderDocuments/fb6ff2b5-0350-4246-9d15-e760ac451f77.pdf

The Board proposed using disciplinary action pursuant to RS677.205 against Licensee for violations of the Clinical Exercise Act, to wit: ORS 677.190(1)(a) unprofessional or dishonorable enable carry out, as outlined in ORS 677.188(four)(a); ORS 677.one hundred ninety(six), conviction of any offense punishable by incarceration within a Section of Punition institution; ORS 677.one hundred ninety(seven) habitual or too much utilization of an intoxicant; ORS 677.one hundred ninety(eight) fraud or misrepresentation in applying for or procuring a license to follow within this state; ORS 677.one hundred ninety(eighteen) willfully violate a board regulation; and ORS 677.one hundred ninety(26) failure by licensee to report on the board any adverse motion taken from the licensee by a governmental or law enforcement company for functions or perform that might constitute grounds for disciplinary action.

3.five In 2009, the Board discovered that Licensee (as a result of his organization ?Alliance Acupuncture, LLC) was advertising and marketing position positions for ?Acupuncture Assistants? at clinics in Portland and Seattle. The positions essential candidates to very first entire a class (having an enrollment cost of $149) like a prerequisite to setting up their eligibility to get an occupation. Licensee labeled the system because ?Acupuncture Help Certification Plan.? His system was ostensibly sponsored by ?National Acupuncture Assistant Certification Council (NAACC).? The NAACC was a paper group without authority or standing that was created and promoted by Licensee as part of the deceptive marketing and advertising scheme.

3.six On April twenty five, 2009, Licensee was noticed driving in an erratic fashion. Responding on the scene, a Marion County Deputy Sheriff decided that Licensee gave the impression to be intoxicated. Licensee was unable to conduct any subject sobriety checks and admitted to owning consumed about 9 beers. Licensee was subsequently arrested and cited for driving underneath the affect of an intoxicant

three.4 Licensee submitted an application for a license to exercise in Oregon that was dated April 27, 2004. He subsequently applied for regime license renewals in an application dated Could 2, 2006, and an application dated April twelve, 2008. Licensee admits that he presented the answers a mentioned underneath to the next problems in his apps for licensure, plus the Board finds that his answers were untruthful:

Dr. Terry McCormick DAOM

Source: http://www.maria.asia/dr-terry-mccormick-daom-fraudulently-obtained-new-york-acupuncture-license/

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Side Effects: The Snails of War, and Other Robotics Experiments

[unable to retrieve full-text content]Electric snails and cockroaches are early forays in a new line of research aimed at creating tiny, self-powered animal/machine hybrids as an alternative to tiny robots.

Source: http://feeds.nytimes.com/click.phdo?i=4c08f8a6e106dfe02e81ea2bf776f4c4

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